Relevant Publications
Metabolic
Selective Glucocorticoid Receptor Modulation Prevents and Reverses Nonalcoholic Fatty Liver Disease in Male Mice
- Koorneef et al.
- 2018
- 30321321
Endocrinology. 2018, 159(12):3925–3936
Oncology
Glucocorticoid receptor expression in 20 solid tumor types using immunohistochemistry assay.
- Block et al.
- 2017
- 28293120
Cancer Manag Res. 2017;9:65-72.
Metabolic
The role of glucocorticoid receptors in metabolic syndrome and psychiatric illness.
- Moraitis et al.
- 2017
- 27002803
J Steroid Biochem Mol Biol. 2017 Jan;165(Pt A):114-120.
Metabolic
Evaluation of evidence of adrenal insufficiency in trials of normocortisolemic patients treated with mifepristone.
- Yuen et al.
- 2017
- 29264481
J Endocr Soc. 2017;1(4):237-246.
Metabolic
Selective glucocorticoid receptor antagonist CORT125281 activates brown adipose tissue and alters lipid distribution in male mice.
- Kroon et al.
- 2017
- 28938459
Endocrinology. 2017 Sep 18. doi:10.1210/en.2017-00512.
Other
Identification of the clinical candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): a selective Glucocorticoid Receptor (GR) antagonist.
- Hunt et al.
- 2017
- 28368581
J Med Chem. 2017;60(8):3405-3421.
Other
Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™).
- Webster et al.
- 2017
- 28012176
Br J Pharmacol. 2017;174(5):396-408.
Other
Assessment of safety, tolerability, pharmacokinetics, and pharmacological effect of orally administered CORT125134: an adaptive, double-blind, randomized, placebo-controlled phase 1 clinical study.
- Hunt et al.
- 2017
- 28967708
Clin Pharmacol Drug Dev. 2017 Oct 2. doi: 10.1002/cpdd.389.
Oncology
Selective Glucocorticoid Receptor Modulators (SGRMs) delay castrate-resistant prostate cancer growth.
- Kach et al.
- 2017
- 28428441
Mol Cancer Ther. 2017;16(8):1680-1692.
Psychiatric
A mixed glucocorticoid/mineralocorticoid receptor modulator dampens endocrine and hippocampal stress responsivity in male rats.
- Nguyen et al.
- 2017
- 28093219
Physiol Behav. 2017;178:82-92.